1. RNA editing, a post transcriptional process, is achieved with the help of guide RNA (g RNA) which one of the following statement about the process is NOT true?
(1) g RNA dependant RNA editing happens in the kinetoplast of DNA.
(2) g-RNA is involved in chemical modification of t-RNA.
(3) This process involves insertion or deletion of uredines.
(4) Sequences edited once may be re-edited using second gRNA.
2.Telomerase, a RNA- protein complex which completes the replication of telomeres during DNA synthesis, is a specialized
(1) RNA dependent DNA polymerase
(2) DNA dependent DNA polymerase
(3) DNA dependent RNA polymerase
(4) RNA dependent RNA polymerase
3.Consider a short double-stranded linear DNA molecule of 10 complete turns with 10.5 bp/ turn. The ends of the DNA molecule are sealed together to make a relaxed circle. This relaxed circle will have a linking number of
(1) 105 (2) 20.5 (3) 10.0 (4) 10.5
4.The secondary antibodies routinely used for the detection of primary antibodies in western blotting experiment are
(1) anti-allotypic (2) anti-idiotypic (3) anti-isotypic (4) anti-paratypic
5.Which of the following events will NOT usually lead to transformation of a normal cell into a cancer cell
(1) Gain of function of oncogenes
(2) Loss of function of tumor suppressors
(3) Gain of function of genes involved in nucleotide excision repair
(4) Loss of function of pro-apoptosis related genes
6. Which of the following a food borne toxin
(1) Tetanus toxin (2) Botulinum toxin (3) Cholera toxin (4) Diptheria toxin
7. Excess oxygen consumed after a vigorous exercise is
(1) to pump out lactic acid from muscle
(2) to increase the concentration of lactic acid in muscle
(3) to reduce dissolved carbon dioxide in blood
(4) to make ATP for gluconeogenesis
8. Which one of the following describes the primary function of flipases?
(1) Help in increasing lipid protein interaction in the outer leaflet of the bilayer
(2) Move certain phospholipids from one leaflet of the membrane to another
(3) Localize more negatively charged membrane proteins in the lipid bilayer
(4) Cause uncoupling of v-SNARES and t-SNARES after fusion of incoming vesicle with target membrane
9. Mitotic cyclin-CDK activity peaks in M phase. This is because
(1) Mitotic cyclin is synthesized only in M phase.
(2) Threshold level of mitotic cyclin accumulates only in late G2.
(3) Cyclin subunit is activated by phosphorylation only in M phase.
(4) The kinase subunit is activated by dephosphorylation only in M phase.
10. Choose the correct statement about peptides in Ramchandran plot.
(1) Peptides that are unstructured will have all the backbone dihedral angles in the disallowed regions.
(2) It is not possible to conclude whether two peptide adopts entirely helix or entirely beta sheet confirmation.
(3) The occurrence of beta turn conformation formation in a peptide can be deduced.
(4) The sequence of a peptide can be deduced.
11. Equilibrium constant (K’eq) of reaction is a ratio of product to substrate concentration. The reaction between (K’eq) and free energy change in a reaction (ΔG’) is follows
ΔG’ = -RT ln K’eq
Reaction A and reaction B have K’eq values of 10 and 100, respectively. Which of the following statement is correct with respect to ΔG’?
(1) ΔG’of A= ΔG’of B (2) ΔG’ of A ˃ ΔG’ of B (3) ΔG’ of B ˃ ΔG’ of A (4) ΔG’ of A ≈ ΔG’ of B
12. The gel to liquid crystalline phase trasition temperature in phosphatidyl choline (PC) lipids compose of dioleoyl (DO), dipalmitoyl (DP), disteroyl (DS) and palmitoyl oleoyl (PO) fatty
acids in increasing order will be
(1) DOPC ˃ DPPC ˃ POPC ˃DSPC
(2) DSPC ˃ DPPC ˃ POPC ˃ DOPC
(3) DPPC ˃ DSPC ˃ DOPC ˃ POPC
(4) POPC ˃ DPPC ˃ DOPC ˃ DSPC
13. Which of the following is NOT an example of trasmembrane transport between different subcellular compartments?
(1) Transport from cytoplasm into lumen of the endoplasmic reticulum
(2) Transport from endoplasmic reticulum to the Golgi complex
(3) Transport from stroma into thylakoid space
(4) Transport from mitochondrial intermembrane space into the mitochondrial matrix
14. Which of the following are NOT transcribed by RNA polymerase II?
(1) miRNA and some snRNA
(2) miRNA and snoRNA
(3) mRNA and snoRNA
(4) tRNA and 5S rRNA
15. Apical ectodermal ridge induction is essential tetrapod limb development. Which of the following is NOT essential for the formation of a functional limb?
(1) Tbx genes and Wnt
(2) Androsterone
(3) Apoptotic gene
(4) Fibroblast growth factor
16. Which of the following statement is WRONG?
(1) Megasporocyte develops within the megasporangium of the ovule
(2) Megasporocyte undergoes meiosis to produce four haploid megaspores
(3) All the four megaspore undergo several mitotic division to form female gametophyte in most angiosperms
(4) Female gametophyte is haploid
17. Certain proteins or mRNAs that are regionally localized within the unfertilized egg and regulate development are called
(1) gene regulators.
(2) morphometric determinants .
(3) cytoplasmic determinants.
(4) mosaic forming factors.
18. Cell to cell communication is important in development of an organism. The ability of cells to respond to a specific inductive signal is called
(1) Regional specificity of induction
(2) Competence
(3) Juxtracrine signalling
(4) Instructive interaction
19. Which one of the following compounds is NOT a part of alkaloid class of secondary metabolites?
(1) Lignin (2) Indole (3) Tropane (4) Pyrroidine
20. Which one of the following best describe the symplast pathway of water flow from the epidermis to endodermis in plant root?
(1) Water moves through cell walls and extracellular spaces without crossing any membrane
(2) Water travel across the root cortex via the plasmodesmata
(3) Water crosses the plasma membrane of each cell in its path twice, once on entering and once on exiting
(4) Transport across the tonoplast
21. The herbicide, dichlorophenyldimethylurea, is an inhibitor of
(1) Shikimate pathway for biosynthesis of aromatic amino acids.
(2) Electron transport from P680 to P700.
(3) Branch in amino acid pathway.
(4) Electron transport from P700 to ferrodoxin.
22. Vasopressin secretion does NOT increase with
(1) Exercise
(2) An increase in extracellular fluid volume
(3) Standing
(4) Vommiting
23. Which one of the following does NOT occur due to stimulation of baroreceptors?
(1) Bradycardia (2) Hypotension (3) Venodialation (4) Vasoconstriction
24. Serum has essentially the same composition as plasma EXCEPT that it lacks
(1) Albumin (2) Stuart-Prower factor (3) Antihemophilic factor (4) Hageman factor
25. Which type of cells located in gastric glands is responsible for the release of histamine?
(1) Mucus neck cells (2) Enterochromaffin like cells (3) Cheif cells (4) Parietal cells
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